$wedge compression fracture treatment ohsu$

$wedge compression fracture treatment ohsu$

Recently, several clinical studies have reported the treatment outcomes of zoledronic acid combined with PKP for OVCFs. ( 7) found that the administration of BPs reduced the occurrence of new fractures in patients with OVCFs treated with percutaneous vertebroplasty. In theory, the application of anti-osteoporosis agents may improve outcomes in patients treated with PKP. To date, the administration of bisphosphonates to treat osteoporosis has been well-studied ( 5, 6). Percutaneous kyphoplasty (PKP), introduced by Garfin et al., has been clinically justified by numerous studies as an effective treatment to quickly relieve pain, correct spinal kyphotic deformities and maintain spinal stabilization in patients with acute OVCFs with persistent and severe pain ( 3).īisphosphonates (BPs) have been confirmed to prevent bone loss and increase bone quality and density by inhibiting osteoclast-mediated bone resorption and decreasing bone turnover ( 4). Osteoporotic vertebral compression fractures (OVCFs) are a major complication of osteoporosis and can result in severe back pain, spinal deformity, the loss of mobility, a decreased quality of life and even death ( 1, 2). The present meta-analysis revealed that zoledronic acid combined with PKP is associated with a higher BMD, a better quality of life, less severe low back pain, and fewer additional vertebral body fractures than is percutaneous vertebral augmentation alone.Ĭonclusions: Compared with PKP only, zoledronic acid combined with percutaneous vertebral augmentation is beneficial for OVCFs.

$wedge compression fracture treatment ohsu$

Results: Three randomized controlled trials (RCTs) and 2 non-RCTs met the inclusion criteria. The statistical analysis was performed with RevMan 5.1. Methods: Eligible scientific articles published prior to July 2020 were retrieved from the PubMed, Springer, ScienceDirect, and Cochrane Library databases. 4Department of Orthopaedics, Tianjin Hospital, Tianjin, Chinaīackground: We performed a meta-analysis to evaluate the efficacy and safety of zoledronic acid combined with percutaneous kyphoplasty (PKP) in treating osteoporotic vertebral compression fractures (OVCFs).3Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.2Department of Spine Surgery, Tianjin Hospital, Tianjin, China.1Department of Traumatic Orthopedics, Tianjin Hospital, Tianjin, China.Peng Tian 1 † Yue Liu 2 † Zhi-jun Li 3 Gui-jun Xu 4 Xin-long Ma 1 *

$wedge compression fracture treatment ohsu$

Wedge compression fracture treatment ohsu